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KMID : 0361519930040020161
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Korean Journal of Psychopharmacology
1993 Volume.4 No. 2 p.161 ~ p.168
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Clinical Efficacy of Clozapine in Treatment-resistant Schizophrenia
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이홍식
이희상/남궁기/김찬형/최낙경/도정호/전지용/황영신/유계준
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Abstract
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To investigate clozapine's effects on both psychopathology and extrapyramidal symptoms in schizophrenia. 25 patients who were treatment-resistant ere entered on 12-week open trial. A total of 2 patients discontinued clozapine treatment before the
end of
the study ; one patient developed pyelone phritis and another patient whose total WBC count was less than 3000/mm3 in weekly hematologic monitoring. stopped the clozapine's trial. Psychopathology and extrapyramidal symptoms were assessed every
two
weeks
until the end of the 12th week using the PANSS. BPRS. CGl. NOSlE. and SimpsonAngus Scale. The mean daily dosage of clozapine was 369±125.0 mg. None of patients received concomitant medications such as hypnotics or anticholinergics during the
study
period. All rating scores on the end study point (N=23) demonstrated a significant improvement compared with baseline. A clinicaliy significant improvement in both positive and negative symptoms was as early as week 2. and maximal improvement in
both
was noted within the first 6week of treatment. 20/23 (87%) patients showed at least a 20% decrease in total PANSs. and 19/23 (83%) in total BPRS. The tolerability of clozapine was generally found to be good. Hypersalivation (87%). drowsiness
(83%).
and
constipation (61%) were the most common side-effects ; only one patient exhibited slight extrapyramidal side effects. Our results suggest that clozapine may be therapeutically superior antipsychotic agent in treating schizophrenia.
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KEYWORD
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